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bioRxiv · 10.64898/2026.06.15.731517

LT-FGRS: a unifying R-package for the estimation of family-based genetic liabilities at population-scale

Pedersen, E. M.·Steinbach, J.·Valstad, M.·Ohlsson, H.·Rasmussen, L. A.·Eilertsen, E. M.·Kendler, K. S.·Vilhjalmsson, B. J.·Schork, A. J.·Krebs, M. D.
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Abstract

Estimates of per-individual genetic liability from large-scale family data are routinely used in biomedical research to describe genetic etiology of traits and disorders, boost the power of gene-mapping studies, and improve risk predictions. Here we present LT-FGRS, an R package for handling population-scale pedigrees and implementing multiple state-of-the-field methods for estimating genetic liability from such data. Benchmarking in population-scale Nordic registry data demonstrates that LT-FGRS reproduces estimates from existing implementations at manageable computational cost. LT-FGRS unifies previous parallel implementations into a single framework, lowering barriers for methodological comparison and applied use. Availability and ImplementationLT-FGRS is available as an R-package on CRAN. (https://CRAN.R-project.org/package=LTFGRS) Contactemp@au.dk; morten.dybdahl.krebs@regionh.dk Supplementary informationhttps://emilmip.github.io/LTFGRS

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Pedersen, E. M., Steinbach, J., Valstad, M., Ohlsson, H., Rasmussen, L. A., Eilertsen, E. M., Kendler, K. S., Vilhjalmsson, B. J., Schork, A. J., Krebs, M. D.. 2026-06-19. LT-FGRS: a unifying R-package for the estimation of family-based genetic liabilities at population-scale. https://doi.org/10.64898/2026.06.15.731517

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