Education and coronary heart disease: a Mendelian randomization study

Tillmann, T.; Vaucher, J.; Okbay, A.; Pikhart, H.; Peasey, A.; Kubinova, R.; Pajak, A.; Tamosiunas, A.; Malyutina, S.; Fischer, K.; Veronesi, G.; Palmer, T.; Bowden, J.; Davey Smith, G.; Bobak, M.; Holmes, M. V.

doi:10.1101/106237

bioRxiv · 10.1101/106237

Education and coronary heart disease: a Mendelian randomization study

Tillmann, T.·Vaucher, J.·Okbay, A.·Pikhart, H.·Peasey, A.·Kubinova, R.·Pajak, A.·Tamosiunas, A.·Malyutina, S.·Fischer, K.·Veronesi, G.·Palmer, T.·Bowden, J.·Davey Smith, G.·Bobak, M.·Holmes, M. V.

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Abstract

ObjectivesTo determine whether educational attainment is a causal risk factor in the development of coronary heart disease.\n\nDesignMendelian randomization study, where genetic data are used as proxies for education, in order to minimize confounding. A two-sample design was applied, where summary level genetic data was analysed from two publically available consortia.\n\nSettingIn the main analysis, we analysed genetic data from two large consortia (CARDIoGRAM and SSGAC), comprising of 112 cohorts from predominantly high-income countries. In addition, we also analysed genetic data from 7 additional large consortia, in order to identify putative causal mediators.\n\nParticipantsThe main analysis was of 589 377 men and women, predominantly of European origin.\n\nExposureA one standard deviation increase in the genetic predisposition towards higher education (i.e. 3.6 years of additional schooling). This was measured by 162 genetic variants that have been previously associated with education.\n\nMain outcomeCombined fatal and nonfatal coronary heart disease (63 746 events).\n\nResults3.6 years of additional education lowered the risk of coronary heart disease by a third (odds ratio = 0.67, 95% confidence interval [CI], 0.59 to 0.77, p=0.01). Equivalent increases in education were also causally associated with reductions in smoking, BMI and improvements in blood lipid profiles.\n\nConclusionsMore time spent in education is causally associated with a large reduction in the risk of coronary heart disease. This may be partly explained by changes to smoking, BMI and a blood lipids. These findings offer support for policy interventions that increase education, in order to also reduce the burden of cardiovascular disease.

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Tillmann, T., Vaucher, J., Okbay, A., Pikhart, H., Peasey, A., Kubinova, R., Pajak, A., Tamosiunas, A., Malyutina, S., Fischer, K., Veronesi, G., Palmer, T., Bowden, J., Davey Smith, G., Bobak, M., Holmes, M. V.. 2017-02-06. Education and coronary heart disease: a Mendelian randomization study. https://doi.org/10.1101/106237

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