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bioRxiv · 10.1101/730978

Low rank mechanisms underlying flexible visual representations

Abstract

Neuronal population responses to sensory stimuli are remarkably flexible. The responses of neurons in visual cortex depend on stimulus properties (e.g. contrast), processes that affect all stages of visual processing (e.g. adaptation), and cognitive processes (e.g attention or task switching). The effects of all of these processes on trial-averaged responses of individual neurons are well-described by divisive normalization, in which responses are scaled by the total stimulus drive. Normalization describes how a staggering variety of sensory, cognitive, and motor processes affect individual neurons (1), but whether different normalization processes could be mediated by the same mechanism remains poorly understood. We and others recently showed that attention has low rank effects on the covariability of populations of neurons in visual area V4 (2-4), which strongly constrains mechanistic models mechanism (2). We hypothesized that measuring changes in population covariability associated with other normalization processes could clarify whether they might share a mechanism. Our experimental design included measurements in multiple visual areas using four normalization processes. We found that contrast, adaptation, attention, and task switching affect the responses of populations of neurons in primate visual cortex in a similarly low rank way. These results suggest that a given circuit uses a common mechanism to perform many forms of normalization and likely reflect a general principle that applies to a wide range of brain areas and sensory, cognitive, or motor processes.

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BibTeXRIS

Ruff, D. A., Xue, C., Kramer, L. E., Baqai, F., Cohen, M. R.. 2019-08-09. Low rank mechanisms underlying flexible visual representations. https://doi.org/10.1101/730978

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