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bioRxiv · 10.1101/618751

Versatile polyketide biosynthesis platform for production of aromatic compounds in yeast

Jakociunas, T.·Klitgaard, A. K.·Romero-Suarez, D.·Petzold, C. J.·Gin, J. W.·Tong, Y.·Frandsen, R. J. N.·Weber, T.·Lee, S. Y.·Krogh Jensen, M.·Keasling, J. D.
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Abstract

To accelerate the shift to bio-based production and overcome complicated functional implementation of natural and artificial biosynthetic pathways to industry relevant organisms, development of new, versatile, bio-based production platforms is required. Here we present a novel yeast platform for biosynthesis of bacterial aromatic polyketides. The platform is based on a synthetic polyketide synthase system enabling a first demonstration of bacterial aromatic polyketide biosynthesis in a eukaryotic host.

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Jakociunas, T., Klitgaard, A. K., Romero-Suarez, D., Petzold, C. J., Gin, J. W., Tong, Y., Frandsen, R. J. N., Weber, T., Lee, S. Y., Krogh Jensen, M., Keasling, J. D.. 2019-04-25. Versatile polyketide biosynthesis platform for production of aromatic compounds in yeast. https://doi.org/10.1101/618751

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