PROGRESSION OF AUTOANTIBODIES ANTI-GAD AND ANTI-IA2 IN TYPE 1A DIABETICS AGED OF 5 TO 21 YEARS IN CÔTE D'IVOIRE

Trebissou, A. F. J.; Yapo-Crezoit, C. C. A.; Sibailly, P.; Sanogo, M.; Ankotche, A.; Kouassi, D.; Kouassi, M. T.; Masmoudi, H.; Yapo, A. F.

doi:10.1101/551473

bioRxiv · 10.1101/551473

PROGRESSION OF AUTOANTIBODIES ANTI-GAD AND ANTI-IA2 IN TYPE 1A DIABETICS AGED OF 5 TO 21 YEARS IN CÔTE D'IVOIRE

Trebissou, A. F. J.·Yapo-Crezoit, C. C. A.·Sibailly, P.·Sanogo, M.·Ankotche, A.·Kouassi, D.·Kouassi, M. T.·Masmoudi, H.·Yapo, A. F.

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Abstract

BackgroundDiabetes autoantibodies are indispensable markers of diabetes classification. Objectiveto research autoantibodies anti-GAD and anti-IA2 in type 1A diabetics (T1D) aged 5 to 21 years, and to follow the progression of these autoantibodies in T1D patients, in Cote dIvoire. MethodsThe study population composed of 28 T1D patients, aged 5 to 21 years. T1D were followed up in two diabetes care centers in Abidjan district, Endocrinology departments of U.H.C of Yopougon and Treichville. Anti-GAD and anti-IA2 autoantibodies were researched by ELISA. Resultsanti-GAD and anti-IA2 were present in T1D and their siblings. After 2 years of diabetes, the titer of the anti-GAD autoantibodies increased to the mean value of 677.10 {+/-} 353.20 IU / ml. Then, a fall of the anti-GAD autoantibodies until the cancellation was observed from the 8th to the 9th with values of 117 IU / ml to 10.14 IU / ml. Anti-IA2 autoantibodies fall at 9th year of diabetes with a value of 55.10 IU / ml. Conclusionanti-GAD and anti-IA2 autoantibodies persist after 9 years of diabetes, causing total destruction over time of the pancreatic {beta}-cell mass in patients from Cote dIvoire, leading them to the death.

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Trebissou, A. F. J., Yapo-Crezoit, C. C. A., Sibailly, P., Sanogo, M., Ankotche, A., Kouassi, D., Kouassi, M. T., Masmoudi, H., Yapo, A. F.. 2019-02-16. PROGRESSION OF AUTOANTIBODIES ANTI-GAD AND ANTI-IA2 IN TYPE 1A DIABETICS AGED OF 5 TO 21 YEARS IN CÔTE D'IVOIRE. https://doi.org/10.1101/551473

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