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bioRxiv · 10.1101/527176

Posttraumatic Stress Disorder and the Social Brain: Affect-Related Disruption of the Default and Mirror Networks

Abstract

BackgroundSocial impairments, specifically in mentalizing and emotion recognition, are common and debilitating symptoms of posttraumatic stress disorder (PTSD). Despite this, little is known about the neural underpinnings of these impairments, as there have been no published neuroimaging investigations of social inference in PTSD. MethodsTrauma-exposed veterans with and without PTSD (N = 20 each) performed the Why/How social inference task during functional magnetic resonance imaging (fMRI). The PTSD group had two fMRI sessions, between which they underwent affect labeling training. We probed the primary networks of the "social brain"--the default mode network (DMN) and mirror neuron system (MNS)--by examining neural activity evoked by mentalizing and action identification prompts, which were paired with emotional and non-emotional targets. ResultsHyperactivation to emotional stimuli differentiated PTSD patients from controls, correlated with symptom severity, and predicted training outcomes. Critically, these effects were generally non-significant for non-emotional stimuli. PTSD-related effects were widely distributed throughout DMN and MNS. Effects were strongest in regions associated with the dorsal attention, ventral attention, and frontoparietal control networks. Unexpectedly, effects were non-significant in core affect regions. ConclusionsThe array of social cognitive processes subserved by DMN and MNS may be inordinately selective for emotional stimuli in PTSD. This selectivity may be tightly linked with attentional processes, as effects were strongest in attention-related regions. Putatively, we propose an attentional account of social inference dysfunction in PTSD, in which affective attentional biases drive widespread affect-selectivity throughout the social brain. This account aligns with numerous findings of affect-biased attentional processing in PTSD.

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BibTeXRIS

Tan, K. M., Burklund, L. J., Craske, M. G., Lieberman, M. D.. 2019-01-23. Posttraumatic Stress Disorder and the Social Brain: Affect-Related Disruption of the Default and Mirror Networks. https://doi.org/10.1101/527176

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