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bioRxiv · 10.1101/361394

Neural oligarchy: how synaptic plasticity breeds neurons with extreme influence

Abstract

Synapses between cortical neurons are subject to constant modifications through synaptic plasticity mechanisms, which are believed to underlie learning and memory formation. The strengths of excitatory and inhibitory synapses in the cortex follow a right-skewed long-tailed distribution. Similarly, the firing rates of excitatory and inhibitory neurons also follow a right-skewed long-tailed distribution. How these distributions come about and how they maintain their shape over time is currently not well understood. Here we propose a spiking neural network model that explains the origin of these distributions as a consequence of the interaction of spike-timing dependent plasticity (STDP) of excitatory and inhibitory synapses and a multiplicative form of synaptic normalisation. Specifically, we show that the combination of additive STDP and multiplicative normalisation leads to lognormal-like distributions of excitatory and inhibitory synaptic efficacies as observed experimentally. The shape of these distributions remains stable even if spontaneous fluctuations of synaptic efficacies are added. In the same network, lognormal-like distributions of the firing rates of excitatory and inhibitory neurons result from small variability in the spiking thresholds of individual neurons. Interestingly, we find that variation in firing rates is strongly coupled to variation in synaptic efficacies: neurons with the highest firing rates develop very strong connections onto other neurons. Finally, we define an impact measure for individual neurons and demonstrate the existence of a small group of neurons with an exceptionally strong impact on the network, that arise as a result of synaptic plasticity. In summary, synaptic plasticity and small variability in neuronal parameters underlie a neural oligarchy in recurrent neural networks.\n\nAuthor summaryOur brains neural networks are composed of billions of neurons that exchange signals via trillions of synapses. Are these neurons created equal, or do they contribute in similar ways to the network dynamics? Or do some neurons wield much more power than others? Recent experiments have shown that some neurons are much more active than the average neuron and that some synaptic connections are much stronger than the average synaptic connection. However, it is still unclear how these properties come about in the brain. Here we present a neural network model that explains these findings as a result of the interaction of synaptic plasticity mechanisms that modify synapses efficacies. The model reproduces recent findings on the statistics of neuronal firing rates and synaptic efficacies and predicts a small class of neurons with exceptionally high impact on the network dynamics. Such neurons may play a key role in brain disorders such as epilepsy.

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BibTeXRIS

Kleberg, F. I., Triesch, J.. 2018-07-03. Neural oligarchy: how synaptic plasticity breeds neurons with extreme influence. https://doi.org/10.1101/361394

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