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bioRxiv · 10.1101/274985

Scalable cytoarchitectonic characterization of large intact human neocortex samples

Hildebrand, S.·Schueth, A.·Herrler, A.·Galuske, R.·Roebroeck, A.
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Abstract

We describe MASH (Multiscale Architectonic Staining of Human cortex): a simple, fast and low-cost cytoarchitectonic labeling and optical clearing approach for human cortex samples, which can be applied to large formalin fixed adult brain samples. A suite of small-molecule fluorescent nuclear and cytoplasmic dyes in combination with new refractive index matching solutions allows deep volume imaging. This enables highly scalable human neocortical cytoarchitecture characterization with a large 3D scope.

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Hildebrand, S., Schueth, A., Herrler, A., Galuske, R., Roebroeck, A.. 2018-03-05. Scalable cytoarchitectonic characterization of large intact human neocortex samples. https://doi.org/10.1101/274985

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