An unconventional myosin, myosin 1d regulates Kupffer’s vesicle morphogenesis and laterality

Saydmohammed, M.; Yagi, H.; Calderon, M.; Clark, M. J.; Feinstein, T.; Sun, M.; Stolz, D. B.; Watkins, S. C.; Amack, J.; Lo, C.; Tsang, M.

doi:10.1101/268789

bioRxiv · 10.1101/268789

An unconventional myosin, myosin 1d regulates Kupffer’s vesicle morphogenesis and laterality

Saydmohammed, M.·Yagi, H.·Calderon, M.·Clark, M. J.·Feinstein, T.·Sun, M.·Stolz, D. B.·Watkins, S. C.·Amack, J.·Lo, C.·Tsang, M.

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Abstract

INTRODUCTION INTRODUCTION RESULTS MATERIALS AND METHODS AUTHOR CONTRIBUTIONS REFERENCES Establishing left-right (LR) asymmetry is a fundamental process essential for arrangement of visceral organs during development. In vertebrates, motile cilia driven fluid flow in the left-right organizer (LRO) is essential for initiating symmetry breaking event1-3. Without a definite LRO structure in invertebrates, LR asymmetry is initiated at a cellular level by actin-myosin driven chirality4, 5. In Drosophila, myosin1D drives tissue-specific chirality in hind-gut looping6, 7. Here, we show that myosin 1d (myo1d) is essential for establishing LR asymmetry in zebrafish. Using super-r ...

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Saydmohammed, M., Yagi, H., Calderon, M., Clark, M. J., Feinstein, T., Sun, M., Stolz, D. B., Watkins, S. C., Amack, J., Lo, C., Tsang, M.. 2018-02-26. An unconventional myosin, myosin 1d regulates Kupffer’s vesicle morphogenesis and laterality. https://doi.org/10.1101/268789

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