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bioRxiv · 10.1101/206953

Dynamic Architecture of DNA Repair Complexes and the Synaptonemal Complex at Sites of Meiotic Recombination

Abstract

Meiotic double-strand breaks (DSBs) are generated and repaired in a highly regulated manner to ensure formation of crossovers (COs) while also enabling efficient non-CO repair to restore genome integrity. Here we use Structured-Illumination Microscopy to investigate the dynamic architecture of DSB repair complexes at meiotic recombination sites in relationship to the synaptonemal complex (SC). DSBs resected at both ends are rapidly converted into inter-homolog repair intermediates harboring two populations of BLM helicase and RPA, flanking a single population of MutS{gamma} . These intermediates accumulate until late pachytene, when repair proteins disappear from non-CO sites and CO-designated sites become enveloped by SC-central region proteins, acquire a second MutS{gamma} population, and lose RPA. These and other data suggest that the SC protects CO intermediates from being dismantled inappropriately and promotes step-wise CO maturation by generating a transient CO-specific repair compartment, thereby enabling differential timing and outcome of repair at CO and non-CO sites

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BibTeXRIS

Woglar, A., Villeneuve, A. M.. 2017-10-20. Dynamic Architecture of DNA Repair Complexes and the Synaptonemal Complex at Sites of Meiotic Recombination. https://doi.org/10.1101/206953

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