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bioRxiv · 10.1101/2025.06.19.660650

Asymmetric increase in episodic and procedural memory interference in older adults

Celik, B.·Kamal, L.·Goldstein, D.·Alpert, G.·Gonzalez, S.·Nguyen, V.·Freedberg, M. V.
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Abstract

In younger adults, newly formed procedural memories are weakened by the subsequent formation of episodic memories (E[->]P interference) and vice versa (P[->]E interference; "cross-memory interference"). Older adults experience significant decline in episodic memory but maintain relatively intact procedural memory. This asymmetric decline in memory may also cause an asymmetric change in cross-memory interference compared to younger adults. For example, older adults may experience a significant increase in one type of cross-memory interference while leaving the other unchanged. Additionally, decline in episodic memory may cause E[->]P interference to either increase or decrease depending on how the episodic and procedural memory systems interact. However, no study to our knowledge has compared cross-memory interference between younger and older adults. We investigated cross-memory interference in younger and older adults by measuring E[->]P (Exp. 1) and P[->]E (Exp. 2) interference in 40 younger (18-40 years old) and 40 older ([≥] 55 years old) adults. Compared to younger adults, the results show that older adults experience significantly stronger E[->]P interference while P[->]E interference was statistically indistinguishable between groups. These results confirm that older adults experience an asymmetric increase in cross-memory interference and suggest that the increase in E[->]P interference is related to the asymmetric decline in episodic memory relative to procedural memory.

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Celik, B., Kamal, L., Goldstein, D., Alpert, G., Gonzalez, S., Nguyen, V., Freedberg, M. V.. 2025-06-26. Asymmetric increase in episodic and procedural memory interference in older adults. https://doi.org/10.1101/2025.06.19.660650

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