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bioRxiv · 10.1101/2025.01.03.631233

Innovations in skin aging: biomimetic exosomes versus natural exosomes

Salvaggio, A.·Privitera, A.·Iannello, G.·Brundo, M. V.
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Abstract

In this study, we compared the effectiveness of two commercial products contain biomimetic and natural exosomes on skin aging used two cells line, keratinocytes and fibroblasts. MTT assay and scratch-wound assay were employed to evaluate their in vitro effects. The treatment with product containing natural exosomes purified from bovine colostrum and loaded with growth factors and cytokines purified from bovine colostrum (AMPLEX PLUS technology), was able to significantly enhance cell proliferation of fibroblasts and keratinocytes at 24 hours compared to cells treatment with product containing biomimetic exosomes and compared to untreated cells (control). Product containing natural exosomes was also able to close the wound scratch after 24 hours. The obtained results suggest that the product containing exosomes derived from bovine colostrum has excellent structural and functional stability offer great potential as natural product for skin aging damage and wound healing.

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Salvaggio, A., Privitera, A., Iannello, G., Brundo, M. V.. 2025-01-03. Innovations in skin aging: biomimetic exosomes versus natural exosomes. https://doi.org/10.1101/2025.01.03.631233

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