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bioRxiv · 10.1101/2024.08.05.606671

A mRNA Vaccine Encoding for a 60-mer G Glycoprotein Nanoparticle Elicits a Robust Neutralizing Antibodies Response Against the Nipah Virus

Brandys, P.·Albarino, C. G.·Jain, S.·Merenkova, I.·Schork, N. J.·Deng, A.·Valiere, M.·Herold, J.
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Abstract

The Nipah virus is a zoonotic pathogen causing encephalitis and acute respiratory illness in humans with very high fatality rates. Here we report a novel messenger RNA vaccine that directly encodes for a nanoparticle displaying 60 head domains of the Nipah virus G (NiV G) glycoprotein that acts as a highly effective antigen. A vaccine encoding for the NiV G nanoparticle elicits high antibody titers against NiV G and a robust neutralizing antibody response with a pseudotyped Nipah virus system. We ultimately find that the proposed mRNA NiV G nanoparticle (mRNA NiV G-NP) provides a flexible platform for the development of vaccines that will likely be of great value in combatting future Nipah virus outbreaks.

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Brandys, P., Albarino, C. G., Jain, S., Merenkova, I., Schork, N. J., Deng, A., Valiere, M., Herold, J.. 2024-08-05. A mRNA Vaccine Encoding for a 60-mer G Glycoprotein Nanoparticle Elicits a Robust Neutralizing Antibodies Response Against the Nipah Virus. https://doi.org/10.1101/2024.08.05.606671

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