Inter-individual variability in motor learning due to differences in effective learning rates between generalist and specialist memory stores

Abstract

Humans exhibit large interindividual differences in motor learning ability. However, most previous studies have examined properties common across populations, with less emphasis on interindividual differences. We hypothesized here, based on our previous experimental and computational motor adaptation studies, that individual differences in effective learning rates between a generalist memory module that assumes environmental continuity and specialist modules that are responsive to trial-by-trial environmental changes could explain both large population-wise and individual-wise differences in dual tasks adaptation under block and random schedules. Participants adapted to two opposing force fields, either sequentially with alternating training blocks or simultaneously with random sequences. As previously reported, in the block training schedule, all participants adapted to the force field presented in a block but showed large interference in the subsequent opposing force field blocks, such that adapting to the two force fields was impossible. In contrast, in the random training schedule, participants could adapt to the two conflicting tasks simultaneously as a group; however, large interindividual variability was observed. A modified MOSAIC computational model of motor learning equipped with one generalist module and two specialist modules explained the observed behavior and variability for wide parameter ranges: when the predictions errors were large and consistent as in block schedules, the generalist module was selected to adapt quickly. In contrast, the specialist modules were selected when they more accurately predicted the changing environment than the generalist, as during random schedules; this resulted in consolidated memory specialized to each environment, but only when the ratio of learning rates of the generalist to specialists was relatively small. This dynamic selection process plays a crucial role in explaining the individual differences observed in motor learning abilities.