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bioRxiv · 10.1101/2024.04.18.590165

Lateral frontoparietal functional connectivity based on individual sulcal morphology

Abstract

A salient neuroanatomical feature of the human brain is its pronounced cortical folding, and there is mounting evidence that sulcal morphology is relevant to functional brain architecture and cognition. However, our understanding of the relationships between sulcal anatomy, brain activity, and behavior is still in its infancy. We previously found the depth of three small, shallow sulci in lateral prefrontal cortex (LPFC) was linked to reasoning performance in childhood and adolescence (Voorhies et al., 2021). These findings beg the question: what is the linking mechanism between sulcal morphology and cognition? To shed light on this question, we investigated functional connectivity among sulci in LPFC and lateral parietal cortex (LPC). We leveraged manual parcellations (21 sulci/hemisphere, total of 1806) and functional magnetic resonance (fMRI) data from a reasoning task from 43 participants aged 7-18 years (20 female). We conducted clustering and classification analyses of individual- level functional connectivity among sulci. Broadly, we found that 1) the connectivity patterns of individual sulci could be differentiated - and more accurately than rotated sulcal labels equated for size and shape; 2) sulcal connectivity did not consistently correspond with that of probabilistic labels or large-scale networks; 3) sulci clustered together into groups with similar patterns, not dictated by spatial proximity; and 4) across individuals, greater depth was associated with higher network centrality for several sulci under investigation. These results highlight that functional connectivity can be meaningfully anchored to individual sulcal anatomy, and demonstrate that functional network centrality can vary as a function of sulcal depth. Significance StatementA salient, and behaviorally relevant, feature of the human brain is its pronounced cortical folding. However, the links between sulcal anatomy and brain function are still poorly understood - particularly for small, shallow, individually variable sulci in association cortices. Here, focusing on individually defined sulci in lateral prefrontal and parietal regions, we offer a novel, anatomically informed approach to defining functional connectomes. Further, we demonstrate, for the first time, a link between functional network centrality and sulcal morphology.

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BibTeXRIS

Hakkinen, S., Voorhies, W. I., Willbrand, E., Tsai, Y.-H., Gagnant, T., Yao, J. K., Weiner, K. S., Bunge, S.. 2024-04-18. Lateral frontoparietal functional connectivity based on individual sulcal morphology. https://doi.org/10.1101/2024.04.18.590165

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