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bioRxiv · 10.1101/2024.03.25.586517

Bettering of Learning Activity through Elevated P-Cresol Levels in the Brain: Insights from Active Avoidance Testing in Wistar Rats

Tevzadze, G.·Zhuravliova, H.·Kikvidze, Z.·Kiknadze, N.·Shetekauri, T.·Tkemaladze, N.
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Abstract

It is established that p-cresol, a compound produced by bacterial colonies within the gastrointestinal tract of mammals, plays a contributory role in the manifestation of various mental disorders. Recently, our research demonstrated that diminishing p-cresol levels in the brain adversely impact the behavioral manifestation of cognitive abilities in rats. In this study, we aimed to investigate the impact of augmenting p-cresol levels in the brain on learning. The Active Avoidance Test was employed to assess learning capabilities. The results, with a high level of confidence, indicated that rats with an increased concentration of p-cresol in the brain exhibited superior task performance and accelerated learning compared to the control group.

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Tevzadze, G., Zhuravliova, H., Kikvidze, Z., Kiknadze, N., Shetekauri, T., Tkemaladze, N.. 2024-03-28. Bettering of Learning Activity through Elevated P-Cresol Levels in the Brain: Insights from Active Avoidance Testing in Wistar Rats. https://doi.org/10.1101/2024.03.25.586517

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