Biology subjects
Publications and source records attributed to Tevzadze, G..
This study demonstrates for the first time how p-cresol and oxytocin influence BDNF expression in pancreatic cancer cells. Specifically, it was found that while treated with p-cresol, an organic compound produced by gastrointestinal bacteria, BDNF expression in pancreatic cancer cells increases. However, while co-treated with oxytocin, a peptide hormone, BDNF expression decreases in these cells.
It is established that p-cresol, a compound produced by bacterial colonies within the gastrointestinal tract of mammals, plays a contributory role in the manifestation of various mental disorders. Recently, our research demonstrated that diminishing p-cresol levels in the brain adversely impact the behavioral manifestation of cognitive abilities in rats. In this study, we aimed to investigate the impact of augmenting p-cresol levels in the brain on learning. The Active Avoidance Test was employed to assess learning capabilities. The results, with a high level of confidence, indicated that rats with an increased concentration of p-cresol in the brain exhibited superior task performance and accelerated learning compared to the control group.