Aβ-affine bifunctional copper chelators capable of Aβ-induced oxidative stress reduction and amyloid disaggregation

Krasnovskaya, O. O.; Abramchuk, D.; Vaneev, A.; Gorelkin, P.; Abakumov, M.; Timoshenko, R.; Chmelyuk, N.; Vadehina, V.; Kuanaeva, R.; Dubrovin, E. V.; Kolmogorov, V.; Beloglazkina, E. K.; Erofeev, A. S.

doi:10.1101/2023.10.10.561649

bioRxiv · 10.1101/2023.10.10.561649

Aβ-affine bifunctional copper chelators capable of Aβ-induced oxidative stress reduction and amyloid disaggregation

Krasnovskaya, O. O.·Abramchuk, D.·Vaneev, A.·Gorelkin, P.·Abakumov, M.·Timoshenko, R.·Chmelyuk, N.·Vadehina, V.·Kuanaeva, R.·Dubrovin, E. V.·Kolmogorov, V.·Beloglazkina, E. K.·Erofeev, A. S.

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Abstract

Alz-5 acts as a bifunctional chelator that can interact with various A{beta} aggregates and reduce their neurotoxicity. Single-cell ROS measurements provided by Pt-nanoelectrode technique revealed a significant antioxidant properties of Alz-5 in A{beta}42 - affected SH-SY5Y cell. AFM data obtained on A{beta}42 fibrils clearly indicate an anti-aggregating property of Alz-5. Youngs modulus mapping on living SH-SY5Y cells revealed an ability of Alz-5 to decrease cell rigidity in A{beta}42 - affected SH-SY5Y cells.

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Krasnovskaya, O. O., Abramchuk, D., Vaneev, A., Gorelkin, P., Abakumov, M., Timoshenko, R., Chmelyuk, N., Vadehina, V., Kuanaeva, R., Dubrovin, E. V., Kolmogorov, V., Beloglazkina, E. K., Erofeev, A. S.. 2023-10-13. Aβ-affine bifunctional copper chelators capable of Aβ-induced oxidative stress reduction and amyloid disaggregation. https://doi.org/10.1101/2023.10.10.561649

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