Aβ-affine bifunctional copper chelators capable of Aβ-induced oxidative stress reduction and amyloid disaggregation
Alz-5 acts as a bifunctional chelator that can interact with various A{beta} aggregates and reduce their neurotoxicity. Single-cell ROS measurements provided by Pt-nanoelectrode technique revealed a significant antioxidant properties of Alz-5 in A{beta}42 - affected SH-SY5Y cell. AFM data obtained on A{beta}42 fibrils clearly indicate an anti-aggregating property of Alz-5. Youngs modulus mapping on living SH-SY5Y cells revealed an ability of Alz-5 to decrease cell rigidity in A{beta}42 - affected SH-SY5Y cells.
pharmacology and toxicology↗