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bioRxiv · 10.1101/2023.05.24.541930

The Striatal Heterodimers A2AR-D2Rs Are Linked To Ergogenic Effects Of Caffeine

Alves, A. C. d. B.·Aguiar, A. S.·Santos, N. d. S.·Tavares, A. P.·Panatta, G.
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Abstract

Adenosine 2A receptors (A2ARs) are abundant in the striatum, and they are found co-localized with dopamine D2 receptors (D2R) and in the heterodimer form A2AR-D2R. Previous we demonstrated that caffeine delays central fatigue through adenosine 2A receptors (A2ARs) antagonism, striatal neuroplasticity and mitochondrial metabolism enhancement. In this study we demonstrate the participation of striatal A2AR-D2R in the ergogenic outcomes. Two-hundred swiss adult mice were treated systemically (i.p.) and centrally (striatum-st.) with caffeine, SCH58261 (A2AR antagonist), DPCPX (A1R antagonist) and haloperidol (D2R antagonist), and performed the open field test, treadmill incremental exercise and grip strength meter test We observed that A2AR-D2R antagonic effects are linked to motor control (p < 0.05) and enhancement of power (p < 0.05). However, the role of A2AR-D2R in the mechanism of strength generation seems to differ from motor control.

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Alves, A. C. d. B., Aguiar, A. S., Santos, N. d. S., Tavares, A. P., Panatta, G.. 2023-05-24. The Striatal Heterodimers A2AR-D2Rs Are Linked To Ergogenic Effects Of Caffeine. https://doi.org/10.1101/2023.05.24.541930

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