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bioRxiv · 10.1101/2022.06.14.495873

A Study of Event-Related Potentials during Monaural and Bilateral Hearing in Single Sided Deaf Cochlear Implant Users

Voola, M. W. R.·Nguyen, A.·Wedekind, A.·Marinovic, W.·Rajan, G.·Tavora-Vieira, D.
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Abstract

ObjectiveSingle sided deafness (SSD) is characterized by a profoundly deaf ear and normal hearing in the contralateral ear. A cochlear implant (CI) is the only method to restore functional hearing in a profoundly deaf ear. In a previous study, we identified that the cortical processing of a CI signal differs from the normal hearing ear (NHE) when directly compared using an auditory oddball paradigms consisting of pure tones. However, it is unclear how the electrical and acoustic signals from each ear are combined. This study aims to understand how the provision of the CI in combination with the NHE may improve SSD CI users ability to discriminate and evaluate auditory stimuli. DesignElectroencephalography (EEG) from ten SSD-CI participants (four participated in the previous pure-tone study) were recorded during a semantic acoustic oddball task, where they were required to discriminate between odd and even numbers. Stimuli were presented in four hearing conditions: directly through the CI, directly to the NHE, or in free field with the CI switched on and off. We examined task-performance (response time and accuracy) and measured N1, P2, N2N4 and P3b event-related brain potentials (ERPs) linked to the detection, discrimination, and evaluation of task relevant stimuli. Sound localization and speech in noise comprehension was also examined. ResultsIn direct presentation, task performance was superior during NHE compared to CI (Shorter and less varied RTs [[~]720 vs. [~]842 ms], higher target accuracy [[~]93 vs. [~]70%]) and early neural responses (N1 and P2) were enhanced for NHE suggesting greater signal saliency. However, the size of N2N4 and P3b target-standard effects did not differ significantly between NHE and CI. In free field, target accuracy was similarly high for both FF-on and -off ([~]95%), with some evidence of CI interference during FF-on (more variable and slightly but significantly delayed RTs [[~]737 vs. [~]709 ms]). Early neural responses and late effects were also greater during FF-on. Performance on sound localization and speech in noise comprehension (SCINNHE configuration only) was significantly greater during CI-on. ConclusionBoth behavioral and neural responses in the semantic oddball task were sensitive to CI in both direct and free-field presentations. Direct conditions revealed that participants could perform the task with the CI alone, although performance was sub-optimal and early neural responses was reduced when compared to the NHE. For free-field, the addition of the CI was associated with enhanced early and later neural responses but did not improved task performance. Enhanced neural responses show that the additional input from the CI is modulating relevant perceptual and cognitive processes, but the benefit of binaural hearing on behavior may not be realized in simple oddball tasks which can be adequately performed with the NHE. Future studies interested in binaural hearing should examine performance under noisy conditions and/or employ spatial cues to allow headroom for the measurement of binaural benefit.

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Voola, M. W. R., Nguyen, A., Wedekind, A., Marinovic, W., Rajan, G., Tavora-Vieira, D.. 2022-06-17. A Study of Event-Related Potentials during Monaural and Bilateral Hearing in Single Sided Deaf Cochlear Implant Users. https://doi.org/10.1101/2022.06.14.495873

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