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bioRxiv · 10.1101/2021.08.24.457558

From Learning to Remembering: How Memory Consolidation Differs in Term and Preterm Born Children from Young Adults

Schommartz, I.·Lembcke, P. F.·Schuetz, H.·Wald de Chamorro, N.·Bauer, M.·Kaindl, A. M.·Buss, C.·Shing, Y. L.
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Abstract

From early to middle childhood, brain regions that underlie memory consolidation undergo profound maturational changes. However, there is little empirical investigation that directly relates age-related differences in brain structural measures to the memory consolidation processes. The present study examined system-level memory consolidations of intentionally studied object-location associations after one night of sleep (short delay) and after two weeks (long delay) in normally developing 5-to-7-year-old children (n = 50) and young adults (n = 39). Behavioural differences in memory consolidation were related to structural brain measures. Our results showed that children, in comparison to young adults, consolidate correctly learnt object-location associations less robustly over short and long delay. Moreover, using partial least squares correlation method, a unique multivariate profile comprised of specific neocortical (prefrontal, parietal, and occipital), cerebellar, and hippocampal subfield structures was found to be associated with variation in short-delay memory consolidation. A different multivariate profile comprised of a reduced set of brain structures, mainly consisting of neocortical (prefrontal, parietal, and occipital), and selective hippocampal subfield structures (CA1-2 and subiculum) was associated with variation in long-delay memory consolidation. Taken together, the results suggest that multivariate structural pattern of unique sets of brain regions are related to variations in short- and long-delay memory consolidation across children and young adults. RESEARCH HIGHLIGHTSO_LIShort- and long-delay memory consolidation is less robust in children than in young adults C_LIO_LIShort-delay brain profile comprised of hippocampal, cerebellar, and neocortical brain regions C_LIO_LILong-delay brain profile comprised of neocortical and selected hippocampal brain regions. C_LIO_LIBrain profiles differ between children and young adults. C_LI

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Schommartz, I., Lembcke, P. F., Schuetz, H., Wald de Chamorro, N., Bauer, M., Kaindl, A. M., Buss, C., Shing, Y. L.. 2021-08-26. From Learning to Remembering: How Memory Consolidation Differs in Term and Preterm Born Children from Young Adults. https://doi.org/10.1101/2021.08.24.457558

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