GABA relates to functional connectivity changes and retention in visuomotor adaptation

Nettekoven, C. R.; Brady, S.; Clarke, W. T.; Emir, U.; Levensteion, J.; Petitet, P.; Panouilleres, M. T. N.; Bachtiar, V.; O'Shea, J.; Johansen-Berg, H.; Jenkinson, N.; Stagg, C.

doi:10.1101/2020.12.22.423981

bioRxiv · 10.1101/2020.12.22.423981

GABA relates to functional connectivity changes and retention in visuomotor adaptation

Nettekoven, C. R.·Brady, S.·Clarke, W. T.·Emir, U.·Levensteion, J.·Petitet, P.·Panouilleres, M. T. N.·Bachtiar, V.·O'Shea, J.·Johansen-Berg, H.·Jenkinson, N.·Stagg, C.

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Abstract

Motor adaptation is fundamental to maintaining accurate movements under changing conditions, but the neurochemical basis of human motor adaptation is not well understood. Here, we used an ultra-high-field MR multimodal acquisition to address the hypothesis that M1 GABA and M1-Cerebellar functional connectivity would relate to retention of adaptation, but not acquisition of adaptation. As such, we demonstrate higher baseline M1 [GABA] relates to greater retention but does not relate to adaptation-acquisition. This relationship is mediated by change in M1-Cerebellar functional connectivity: higher M1 [GABA] relates to a decreased M1-Cerebellar connectivity, resulting in greater retention. These findings showed anatomical, neurochemical and behavioural specificity: As expected, no relationship was found between retention and a control metabolite, retention and connectivity change between control regions and between M1 [GABA] and behaviour in a control condition. The implication of a mechanistic link from neurochemistry to retention advances our understanding of population variability in retention and provides a step towards therapeutic interventions to restore motor abilities.

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Nettekoven, C. R., Brady, S., Clarke, W. T., Emir, U., Levensteion, J., Petitet, P., Panouilleres, M. T. N., Bachtiar, V., O'Shea, J., Johansen-Berg, H., Jenkinson, N., Stagg, C.. 2020-12-22. GABA relates to functional connectivity changes and retention in visuomotor adaptation. https://doi.org/10.1101/2020.12.22.423981

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