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bioRxiv · 10.1101/2020.11.13.380444

Investigation of reward learning and feedback sensitivity in non-clinical participants with a history of early life stress

Abstract

Early life stress (ELS) is an important risk factor for the development of depression. Impairments in reward learning and feedback sensitivity are suggested to be an intermediate phenotype in depression aetiology therefore we hypothesised that similar impairments are present in healthy adults with a history of ELS. We recruited 64 adults with high levels of ELS and no diagnosis of a current mental health disorder and 65 controls. Participants completed the probabilistic reversal learning task and probabilistic reward task followed by depression, anhedonia, social status, and stress scales. Participants with high levels of ELS showed decreased positive feedback sensitivity in the probabilistic reversal learning task compared to controls. High ELS participants also trended towards possessing a decreased model-free learning rate. This was coupled with a decreased learning ability in the acquisition phase of block 1 following the practice session. Neither group showed a reward induced response bias in the probabilistic reward task however high ELS participants exhibited decreased stimuli discrimination. Due to the PRT not meeting its primary endpoint a separate cohort of control participants were tested in a modified PRT where they showed a response bias. This indicates the PRT can be successfully carried out online. Overall, these data suggest that healthy participants without a mental health diagnosis and high levels of ELS show deficits in positive feedback sensitivity and reward learning in the probabilistic reversal learning task that are distinct from depressed patients. These deficits may be relevant to increased depression vulnerability.

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BibTeXRIS

Wilkinson, M. P., Mellor, J. R., Robinson, E. S. J.. 2020-11-13. Investigation of reward learning and feedback sensitivity in non-clinical participants with a history of early life stress. https://doi.org/10.1101/2020.11.13.380444

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