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bioRxiv · 10.1101/2020.10.05.327395

In vivo human whole-brain Connectom diffusion MRI dataset at 760 μm isotropic resolution

Wang, F.·Dong, Z.·Tian, Q.·Liao, C.·Fan, Q.·Hoge, W. S.·Keil, B.·Polimeni, J. R.·Wald, L. L.·Huang, S. Y.·Setsompop, K.
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Abstract

We present a whole-brain in vivo diffusion MRI (dMRI) dataset acquired at 760 m isotropic resolution and sampled at 1260 q-space points across 9 two-hour sessions on a single healthy subject. The creation of this benchmark dataset is possible through the synergistic use of advanced acquisition hardware and software including the high-gradient-strength Connectom scanner, a custom-built 64-channel phased-array coil, a personalized motion-robust head stabilizer, a recently developed SNR-efficient dMRI acquisition method, and parallel imaging reconstruction with advanced ghost reduction algorithm. With its unprecedented resolution, SNR and image quality, we envision that this dataset will have a broad range of investigational, educational, and clinical applications that will advance the understanding of human brain structures and connectivity. This comprehensive dataset can also be used as a test bed for new modeling, sub-sampling strategies, denoising and processing algorithms, potentially providing a common testing platform for further development of in vivo high resolution dMRI techniques. Whole brain anatomical T1-weighted and T2-weighted images at submillimeter scale along with field maps are also made available.

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Wang, F., Dong, Z., Tian, Q., Liao, C., Fan, Q., Hoge, W. S., Keil, B., Polimeni, J. R., Wald, L. L., Huang, S. Y., Setsompop, K.. 2020-10-07. In vivo human whole-brain Connectom diffusion MRI dataset at 760 μm isotropic resolution. https://doi.org/10.1101/2020.10.05.327395

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