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bioRxiv · 10.1101/2020.05.15.097840

Direct and indirect effects of maternal, paternal, and offspring genotypes: Trio-GCTA

Eilertsen, E. M.·Jami, E. S.·McAdams, T. A.·Hannigan, L. J.·Havdahl, A. S.·Magnus, P. M.·Evans, D. M.·Ystrom, E.
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Abstract

Indirect genetic effects from relatives may result in misleading quantifications of heritability, but can also be of interest in their own right. In this paper we propose Trio-GCTA, a model for separating direct and indirect genetic effects when genome-wide single nucleotide polymorphism data have been collected from parent-offspring trios. The model is applicable to phenotypes obtained from any of the family members. We discuss appropriate parameter interpretations and apply the method to four exemplar phenotypes; offspring birth weight, offspring temperament, maternal relationship satisfaction, and paternal body-mass index, using real data from the Norwegian Mother, Father and Child Cohort Study (MoBa).

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Eilertsen, E. M., Jami, E. S., McAdams, T. A., Hannigan, L. J., Havdahl, A. S., Magnus, P. M., Evans, D. M., Ystrom, E.. 2020-05-16. Direct and indirect effects of maternal, paternal, and offspring genotypes: Trio-GCTA. https://doi.org/10.1101/2020.05.15.097840

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