TrkB activation in Parvalbumin interneurons orchestrates cortical plasticity

Winkel, F.; Voigt, M. B.; Didio, G.; Mateo, S.; Jetsonen, E.; Llach Pou, M.; Steinzeig, A.; Ryazantseva, M.; Harkki, J.; Englund, J.; Khirug, S.; Rivera, C.; Palva, S.; Taira, T.; Lauri, S.; Umemori, J.; Castren, E.

doi:10.1101/2020.04.27.063503

bioRxiv · 10.1101/2020.04.27.063503

TrkB activation in Parvalbumin interneurons orchestrates cortical plasticity

Winkel, F.·Voigt, M. B.·Didio, G.·Mateo, S.·Jetsonen, E.·Llach Pou, M.·Steinzeig, A.·Ryazantseva, M.·Harkki, J.·Englund, J.·Khirug, S.·Rivera, C.·Palva, S.·Taira, T.·Lauri, S.·Umemori, J.·Castren, E.

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Abstract

Activation state of Parvalbumin (PV) interneurons regulates neuronal plasticity, driving the closure of developmental critical periods and alternating between high and low plasticity states in response to experience in adulthood. We now show that PV plasticity states are regulated through the activation of TrkB neurotrophin receptors. Activation of an optically activatable TrkB (optoTrkB) specifically in PV interneurons switches adult cortical networks into a state of elevated plasticity within minutes by decreasing excitability of PV neurons. OptoTrkB activation induces changes in gene expression related to neuronal plasticity and excitability, and increases the phosphorylation of Kv3.1 channels. OptoTrkB activation shifted cortical networks towards a low PV configuration, promoting oscillatory synchrony and ocular dominance plasticity. Visual plasticity induced by fluoxetine was lost in mice lacking TrkB in PV neurons. Our data suggest a novel mechanism that dynamically regulates PV interneurons configuration state and orchestrates cortical networks during adulthood. Graphical Abstract O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=171 SRC="FIGDIR/small/063503v2_ufig1.gif" ALT="Figure 1"> View larger version (54K): org.highwire.dtl.DTLVardef@4c521corg.highwire.dtl.DTLVardef@a2ec04org.highwire.dtl.DTLVardef@353775org.highwire.dtl.DTLVardef@1cc0448_HPS_FORMAT_FIGEXP M_FIG C_FIG

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Winkel, F., Voigt, M. B., Didio, G., Mateo, S., Jetsonen, E., Llach Pou, M., Steinzeig, A., Ryazantseva, M., Harkki, J., Englund, J., Khirug, S., Rivera, C., Palva, S., Taira, T., Lauri, S., Umemori, J., Castren, E.. 2020-04-28. TrkB activation in Parvalbumin interneurons orchestrates cortical plasticity. https://doi.org/10.1101/2020.04.27.063503

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