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bioRxiv · 10.1101/2020.01.27.922005

Symmetry structures in dynamic models of biochemical systems

Ohlsson, F.·Borgqvist, J.·Cvijovic, M.
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Abstract

Symmetries provide a powerful concept for the development of mechanistic models by describing structures corresponding to the underlying dynamics of biological systems. In this paper, we consider symmetries of the non-linear Hill model describing enzymatic reaction kinetics, and derive a class of symmetry transformations for each order n of the model. We consider a minimal example consisting in the application of symmetry based methods to a model selection problem, where we are able to demonstrate superior performance compared to ordinary residual-based model selection. Finally, we discuss the role of symmetries in systematic model building in systems biology.

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Ohlsson, F., Borgqvist, J., Cvijovic, M.. 2020-01-28. Symmetry structures in dynamic models of biochemical systems. https://doi.org/10.1101/2020.01.27.922005

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