Is cathodal prefrontal transcranial direct current stimulation capable of affecting inhibitory control and sustained attention? A single-blind, crossover,sham-controlled study

Canabarro, S. L. d. S.; Paniago, C. K.; Santos, P. M.; Rosa, L. S.; Borges, V. E. L.; McManus, D. P.; Garcia, A.; Satler, C.; Brasil-Neto, J. P.; Tavares, M. C. H.

doi:10.1101/2020.01.20.912287

bioRxiv · 10.1101/2020.01.20.912287

Is cathodal prefrontal transcranial direct current stimulation capable of affecting inhibitory control and sustained attention? A single-blind, crossover,sham-controlled study

Canabarro, S. L. d. S.·Paniago, C. K.·Santos, P. M.·Rosa, L. S.·Borges, V. E. L.·McManus, D. P.·Garcia, A.·Satler, C.·Brasil-Neto, J. P.·Tavares, M. C. H.

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Abstract

BackgroundAnodal transcranial direct current stimulation (a-tDCS) has been shown to promote performance improvement of normal individuals in tests of executive function, including tasks that demand sustained attention and inhibitory control. The presumed mechanism is facilitation of prefrontal cortex activation, since a-tDCS is thought to increase cortical excitability. Only a few studies, however, have investigated the effects of inhibitory, cathodal tDCS (c-tDCS) on cognitive tasks, and reported results are often inconsistent. Studies about the effects of c-tDCS upon accuracy and reaction times are particularly scant. Objective/HypothesisThis study assessed the effects of inhibitory c-tDCS over the left dorsolateral prefrontal cortex (l-DLPFC) on the performance of neurologically intact young adults in Stroop and reaction time tests. MethodsSeventeen healthy undergraduate students (ten women) performed Stroop and reaction time tasks after delivery of c-tDCS (1 mA, 20 min) over l-DLFPC or a sham session. All subjects underwent both real and sham sessions, which were separated by an interval of one week. We hypothesized that c-tDCS might lead to an impairment of inhibitory control and attention abilities. ResultsWe found an interference effect on the Stroop task and also a ceiling effect on the reaction Time task. There were no statistically significant performance differences in any of the neuropsychological tests as a function of stimulation condition and/or subject gender. ConclusionsC-tDCS over the l-DLPFC of neurologically intact young individuals did not affect performance in Stroop Test accuracy or in reaction times, irrespective of subject gender. These results raise the possibility that c-tDCS inhibitory effects, well documented for the primary motor area, do not necessarily apply to higher order associative areas. The assumption that c-tDCS has inhibitory effects upon any cortical area, common in clinical trials, should be made with caution.

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Canabarro, S. L. d. S., Paniago, C. K., Santos, P. M., Rosa, L. S., Borges, V. E. L., McManus, D. P., Garcia, A., Satler, C., Brasil-Neto, J. P., Tavares, M. C. H.. 2020-01-21. Is cathodal prefrontal transcranial direct current stimulation capable of affecting inhibitory control and sustained attention? A single-blind, crossover,sham-controlled study. https://doi.org/10.1101/2020.01.20.912287

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