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bioRxiv · 10.1101/133827

Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices

Laurin, C. A.·Cuellar-Partida, G.·Hemani, G.·Davey Smith, G.·Yang, J.·Evans, D. M.
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Abstract

Introduction Introduction Methods Statistical Methods Results Discussion References Parent-of-origin effects (POEs) describe the phenomenon in which the effects of alleles depend upon their parental origin. POEs imply that heterozygote individuals have phenotypes which are distributed differently depending upon which of their alleles were maternally and paternally transmitted (Guilmatre and Sharp 2012; Lawson et al. 2013). The extreme case of POEs is polar overdominance, where the two heterozygotes' phenotypes differ in distribution but the two homozygotes share the same distribution (Hoggart et al. 2014). Imprinting, a phenomenon in which one parent's allele is not expressed, is probably the most widely studied example of POE (Peters 2 ...

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Laurin, C. A., Cuellar-Partida, G., Hemani, G., Davey Smith, G., Yang, J., Evans, D. M.. 2017-05-31. Partitioning Phenotypic Variance Due To Parent-Of-Origin Effects Using Genomic Relatedness Matrices. https://doi.org/10.1101/133827

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