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bioRxiv · 10.1101/106807

The depletion of MARVELD1 leads to placenta accreta via integrin β4-dependent trophoblast cell invasion

Chen, Y.·Zhang, H.·Han, F.·Yue, L.·Qiao, C.·Zhang, Y.·Dou, P.·Liu, W.·Li, Y.
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Abstract

AstractThe mammalian placenta is a remarkable organ. It serves as the interface between the mother and the fetus. Proper invasion of trophoblast cells into the maternal decidua is required for a successful pregnancy. Previous studies have found that the adhesion molecule integrin {beta}4 plays important roles during trophoblast cell invasion. Here, we found that the overall birth rate of the MARVELD1 knockout mouse is much lower than that of the wild-type mouse (P<0.001). In E18.5 MARVELD1 knockout mice, we observed an over-invasion of trophoblast cells, and indeed, the pregnant mice had a partial placenta accreta phenotype. The HTR8/SVneo cell line was used as an in vitro model to elucidate the underlying mechanisms of MARVELD1-mediated trophoblast invasion. We detected a diminished expression of integrin {beta}4 upon the downregulation of MARVELD1 and enhanced migration and invasive abilities of trophoblast cells both in vivo and in vitro. The integrin {beta}4 rescue assay also supported the results. In conclusion, this study found that MARVELD1 mediated the invasion of trophoblast cells via regulating the expression of integrin {beta}4.

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Chen, Y., Zhang, H., Han, F., Yue, L., Qiao, C., Zhang, Y., Dou, P., Liu, W., Li, Y.. 2017-02-07. The depletion of MARVELD1 leads to placenta accreta via integrin β4-dependent trophoblast cell invasion. https://doi.org/10.1101/106807

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