Biology subjects

Wade, R. L.

Publications and source records attributed to Wade, R. L..

3 recordsLinked to original sources

bioRxiv2023

Effectiveness of an ultraviolet-C disinfection system for inactivating Clostridioides difficile spores in critical areas of a simulated patient room

Clostridioides difficile infections (CDI) pose a significant threat to patient safety in healthcare facilities. In this study, we investigated the effectiveness of an ultraviolet-C (UV-C) disinfection system in reducing C. difficile surface contamination in a simulated patient room. The results showed an overall 98.17% reduction in C. difficile spores after UV-C treatment of directly exposed and shadowed areas, an efficiency that translated to a 4.91% reduction per minute of room vacancy. This study demonstrates that UV-C disinfection is an effective method for reducing C. difficile spores in healthcare settings, and that efficiency can be improved with shorter setup times and optimal device placement.

microbiology↗

bioRxiv2022

Rapid inactivation of vaccinia, a surrogate virus for monkeypox and smallpox, using ultraviolet-C disinfection

Human monkeypox is an emerging health threat that has the potential to cause serious sequelae. Ultraviolet-C (UV-C) disinfection is a physical process that triggers microbial inactivation through irreversible DNA damage. A high-output mobile UV-C unit was evaluated against vaccinia, a monkeypox surrogate, for antimicrobial efficacy. In under 7 minutes, a single UV-C cycle had a virucidal efficacy of [≥] 99.996 % in a 200 sq feet area. UV-C technology is a promising strategy for infection prevention and control in the post-COVID era.

molecular biology↗

bioRxiv2022

Real-time inactivation of airborne SARS-CoV-2 using ultraviolet-C

COVID-19 is a life-threatening respiratory infection that has had a profound impact on indoor air quality awareness. Ultraviolet-C (UV-C) is a physical disinfection process that triggers microbial inactivation through creating irreversible genetic material damage. An upper room device equipped with germicidal UV-C (UR GUV) was evaluated against airborne SARS-CoV-2 for antimicrobial efficacy using a robust aerosol testing protocol. In 30 minutes, it led to a virucidal efficacy of 99.994 % in a large, room-sized chamber. UR GUV is a promising mitigation strategy for airborne pathogens.

microbiology↗