Diffusion Acceleration with Gaussian process Estimated Reconstruction (DAGER)
PurposeImage acceleration provides multiple benefits to diffusion MRI (dMRI), with in-plane acceleration reducing distortion and slice-wise acceleration increasing the number of directions that can be acquired in a given scan time. However, as acceleration factors increase, the reconstruction problem becomes ill-conditioned, particularly when using both in-plane acceleration and simultaneous multi-slice (SMS) imaging. In this work, we develop a novel reconstruction method for in-vivo MRI acquisition that provides acceleration beyond what conventional techniques can achieve.\n\nTheory and MethodsWe propose to constrain the reconstruction in the spatial (k) domain by incorporating information from the angular (q) domain. This approach exploits smoothness of the signal in q-space using Gaussian processes, as has previously been exploited in post-reconstruction analysis. We demonstrate in-plane acceleration exceeding the theoretical parallel imaging limits, and SMS combined with in-plane acceleration at a total factor of 12. This reconstruction is cast within a Bayesian framework that incorporates estimation of smoothness hyper-parameters, with no need for manual tuning.\n\nResultsSimulations and in vivo results demonstrate superior performance of the proposed method compared with conventional parallel imaging methods. These improvements are achieved without loss of spatial or angular resolution and require only a minor modification to standard pulse sequences.\n\nConclusionThe proposed method provides improvements over existing methods for diffusion acceleration, particularly for high SMS acceleration with in-plane undersampling.