Biology subjects

Mar Royuela García

Publications and source records attributed to Mar Royuela García.

2 recordsLinked to original sources

bioRxiv2015

Relationship between tumor grade and geometrical complexity in prostate cancer

Prostate cancer exhibits high mathematical complexity due to the disruption of tissue architecture. An important part of the diagnostic of prostate tumor samples is the histological evaluation of cellular and glandular organization. The Gleason grade and score, a commonly used prognostic indicator of patient outcome, is based on the match of glandular architectural patterns with standard patterns. Unfortunately, the subjective nature of visual grading leads to variations in scoring by different pathologists. We proposed the fractal dimension of the lumen and the Lempel-Zip complexity of the histopathological patterns as useful descriptors aiding pathologist to standardize histological classification and thus prognosis and therapy planning.\n\nHighlightsO_LIgeometrical complexity of prostate cancer\nC_LI

Bioinformatics↗

bioRxiv2014

Phase transitions in tumor growth: II prostate cancer cell lines

We propose a mechanism for prostate cancer cell lines growth, e.g., LNCaP and PC3 based on a Gompertz dynamics. This growth exhibits a multifractal behavior and a \"second order\" phase transition. Finally, it was found that the cellular line PC3 exhibits a higher value the entropy production rate compared to LNCaP, which is indicative of the robustness of PC3, over to LNCaP and may be a quantitative index of metastatic potential tumors.\n\nHighlightsO_LICancer is an open, complex, dynamic and self-organizing system.\nC_LIO_LIProstate cancer cell lines growth follows a Gompertz dynamics\nC_LIO_LIProstate cancer cell lines exhibit a multifractal behavior\nC_LIO_LIThe entropy production rate may be considered as metastatic potential marker\nC_LI

Biophysics↗