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Grace, P.

Publications and source records attributed to Grace, P..

2 recordsLinked to original sources

A Multi-Model Ensemble Reveals Soil Carbon Gains from Regenerative Practices in the U.S. Midwest Cropland

Process-based cropping systems models (CSMs) are key components of measurement, monitoring, reporting, and verification (MMRV) frameworks of carbon markets, but their application suffers from model-specific differences that keep any one model from working well across all combinations of soils, climates, crops, and agronomic practices at varying scales. Multi-model ensemble (MME), successfully used to quantify soil, management and climate impact on crop productivity, provide an opportunity to better estimate changes in soil organic carbon (SOC) outcomes for agronomic practices that have the potential to mitigate SOC loss at scale. We used an MME across 46 million hectares of US Midwest cropland at a resolution of 4- km2 to assess the aggregate ability of different regenerative practices to sequester SOC at this scale compared to their dynamic baselines. MME was validated with long-term experimental data and compared to its constituent CSMs, showing greater accuracy and lower uncertainty. The results show that adopting no-till combined with cover crops increased SOC stocks by 0.36 {+/-} 0.12 Mg ha-1 yr-1 aggregated across the entire U.S. Midwest cropland. At the regional scale, this corresponds to a net SOC gain of 16.4 Tg C yr-1 compared to business-as-usual baselines. These benefits are approximately halved when each management change is practiced individually, and the modest gains are only fully realized when continued over the long-term in soils with low initial carbon stock. Results demonstrate the power of MMEs run at high resolution for providing robust estimates of environmental outcomes following agricultural practice change, and for pinpointing locations for most effective intervention. This approach can alleviate many producer carbon market participation barriers and help address market issues while ultimately supporting large-scale regenerative agriculture initiatives.

ecology↗

Systemic and targeted activation of Nrf2 reverses doxorubicin-induced cognitive impairments and sensorimotor deficits in mice

While cancer survivorship has increased due to advances in treatments, chemotherapy often carries long-lived neurotoxic side effects which reduce quality of life. Commonly affected domains include memory, executive function, attention, processing speed and sensorimotor function, colloquially known as chemotherapy-induced cognitive impairment (CICI) or "chemobrain". Oxidative stress and neuroimmune signaling in the brain have been mechanistically linked to the deleterious effects of chemotherapy on cognition and sensorimotor function. With this in mind, we tested if activation of the master regulator of antioxidant response nuclear factor E2-related factor 2 (Nrf2) alleviates cognitive and sensorimotor impairments induced by doxorubicin. The FDA-approved systemic Nrf2 activator, diroximel fumarate (DRF) was used, along with our recently developed prodrug 1c which has the advantage of specifically releasing monomethyl fumarate at sites of oxidative stress. DRF and 1c both reversed doxorubicin-induced deficits in executive function, spatial and working memory, as well as decrements in fine motor coordination and grip strength, across both male and female mice. Both treatments reversed doxorubicin-induced loss of synaptic proteins and microglia phenotypic transition in the hippocampus. Doxorubicin-induced myelin damage in the corpus callosum was reversed by both Nrf2 activators. These results demonstrate the therapeutic potential of Nrf2 activators to reverse doxorubicin-induced cognitive impairments, motor incoordination, and associated structural and phenotypic changes in the brain. The localized release of monomethyl fumarate by 1c has the potential to diminish unwanted effects of fumarates while retaining efficacy.

neuroscience↗