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Degani, G.

Publications and source records attributed to Degani, G..

2 recordsLinked to original sources

Faunal and Floral Assemblages of the Zavitan (Zvitan) Stream near Katzrin (Central Golan Heights, Israel) and Their Influence on Amphibians

The Zvitan (Zavitan) Stream is one of the major basaltic drainage systems of the Levant Region in Israel. The present short communication focuses specifically on the sector adjacent to Katzrin, integrating geomorphological, hydrological, ecological, and amphibian distribution data within the broader watershed context. The stream originates in the central Golan plateau and flows westward into the Yehudiya Reserve before joining the Meshushim Stream and ultimately draining into Lake Kinneret. In the Katzrin sector, the stream is characterized by deeply incised basalt canyons, winter spring discharge and semi-permanent pools sustained by springs and seepage. Seasonal hydrological fluctuations strongly influence aquatic habitats and amphibian breeding success. Amphibian species documented in the Golan Heights include Salamandra salamandra infraimmaculata, Triturus vittatus (currently Ommatotriton vittatus), Hyla savignyi, Bufotes viridis, Pelophylax bedriagae (formerly Rana ridibunda), and Pelobates syriacus. Their distribution is closely associated with water availability, elevation, temperature, and hydroperiod, as demonstrated in northern Israel habitats. The Katzrin sector of Zvitan represents an intermediate ecological zone where Mediterranean and steppe elements converge, creating heterogeneous amphibian assemblages. This observation, carried out at a specific site in the Zavitan Stream, aimed to examine the ecological conditions and identify which amphibian species inhabit this pool, where environmental conditions may differ from those in the main stream channel.

ecology↗

Goat PRP14 (gPRP14) has xeno-antigenic properties and works as a vaccine in preclinical models of cancer.

We studied the activity of recombinant goat PRP14 (gPRP14), a member of the RID protein family, as a xeno-antigen in preclinical models of cancer. Antisera from rabbits and mice immunized with gPRP14 showed strong reactivity against several tumor cell types, which was absent towards normal cells: the tumor selectivity was related to surface and intra-cellular expression in tumor cells, and to an exclusively intra-cellular localization in normal cells. In vitro, binding to tumor cells was followed by cytotoxicity which could be rescued by the addition of excess soluble antigen. In vivo, an anti-tumor activity of immunization with gPRP14 was observed in murine syngeneic models of breast cancer and melanoma: the anti-tumor response was present when gPRP14 was administered in a preventive setting, and persisted upon repeated challenges with tumor cells in long-term survivor mice. Finally, we showed that both the humoral and T-cell mediated responses are needed for the optimal anti-tumor effect in the murine melanoma model. Thus, we have performed an initial characterization of gPRP14 as a cancer vaccine, which -given the potential wide range of tumor cells positive for the antigen-appears as a promising, novel immunotherapy.

cancer biology↗