A network of syringe-injectable bioelectronics for closed-loop therapeutic rescue

Jackson, J.; Sohn, W.; Testu, L.; Ghanim, R.; Aamir, M.; Angia, M.; Cig, A.; Healy, S.; Lee, Z.; Chin, J. Y.; Ding, J. Z.; Park, J.; Maisha, J.; Lee, Y. J.; Abramson, A.

doi:10.64898/2026.11.10.765435

bioRxiv · 10.64898/2026.11.10.765435

A network of syringe-injectable bioelectronics for closed-loop therapeutic rescue

Jackson, J.·Sohn, W.·Testu, L.·Ghanim, R.·Aamir, M.·Angia, M.·Cig, A.·Healy, S.·Lee, Z.·Chin, J. Y.·Ding, J. Z.·Park, J.·Maisha, J.·Lee, Y. J.·Abramson, A.

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Abstract

An on-body network of sensors and drug delivery implants could transform treatments for rapid-onset morbidities that require bystander intervention. During opioid overdoses, for example, lone and incapacitated victims often cannot self-administer life-saving naloxone in the minutes before respiratory collapse. However, the bulkiness of existing closed-loop systems threatens patient acceptance. Here, we present the Rapid Emergency Subcutaneous platform (RES-Q), a network of wearable sensors and syringe-implantable autoinjectors for closed-loop therapy. RES-Q implants are similar in size to FDA-approved drug rod implants and fit inside 6-gauge needles to facilitate outpatient administration. Informed by implant fibrosis fracture mechanics, RES-Q employs miniature jet injectors that deliver 0.4 mg human-relevant doses of naloxone through fibrotic encapsulation for rapid uptake. RES-Q implants communicate with wearable sensors through tissue conductivity, resulting in 25 nA standby current draws that ensure long-term functionality. In swine, we sequentially trigger multiple implants using ionic tissue communication. In rats, RES-Q detects fentanyl overdoses using wearable photoplethysmography sensors and performs autonomous, dose-titratable rescue in < 6 minutes.

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Jackson, J., Sohn, W., Testu, L., Ghanim, R., Aamir, M., Angia, M., Cig, A., Healy, S., Lee, Z., Chin, J. Y., Ding, J. Z., Park, J., Maisha, J., Lee, Y. J., Abramson, A.. 2026-11-12. A network of syringe-injectable bioelectronics for closed-loop therapeutic rescue. https://doi.org/10.64898/2026.11.10.765435

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