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bioRxiv · 10.64898/2026.11.06.764867

Visual capture of the head-direction signal in a rat model of Fragile X Syndrome

Duszkiewicz, A. J.·Rastedt, A. A.·Vadher, A.·Wood, E. R.·Peyrache, A.·Dudchenko, P. A.
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Abstract

Fragile X Syndrome (FXS) is a common inherited monogenic cause of autism spectrum disorder and intellectual disability (ASD/ID), conditions frequently associated with altered sensory processing and multisensory integration. However, the circuit mechanisms underlying these alterations remain poorly understood. Here, we investigate the integration of visual and self-motion information in the head-direction (HD) system in a rat model of FXS (Fmr1-/y rats). Using high-density silicon probes, we recorded neuronal activity in the postsubiculum (PoSub), a cortical hub of the HD system, while adult Fmr1-/y and wild-type (WT) rats experienced repeated rotations of a visual landmark. In WT rats, the HD signal only partially followed landmark rotations, consistent with weighted integration of visual and self-motion information, and visual landmark control progressively weakened across repeated cue conflicts. In contrast, the HD signal in Fmr1-/y rats closely followed landmark rotations and failed to show experience-dependent recalibration. This enhanced visual capture was accompanied by reduced angular head velocity tuning in PoSub neurons, indicating weakened representation of self-motion information. Together, these findings reveal an altered balance between visual and self-motion inputs to the HD system in a rat model of FXS and identify a possible circuit-level mechanism through which sensory integration of vision and self-motion may be disrupted in ASD/ID.

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Duszkiewicz, A. J., Rastedt, A. A., Vadher, A., Wood, E. R., Peyrache, A., Dudchenko, P. A.. 2026-11-09. Visual capture of the head-direction signal in a rat model of Fragile X Syndrome. https://doi.org/10.64898/2026.11.06.764867

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