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bioRxiv · 10.64898/2026.11.06.764820

BEHAV3D-Explorer enables natural language-assisted profiling of 3D cellular dynamics

de Blank, S.·Rios-Jimenez, E.·Rubio-Munoz, A.·Hoffman, O.·Vervoort, B. M. T.·Wezenaar, A. K. L.·Mazalo, J. K.·Molina-Moreno, M.·Chang, H.-F.·Wehrens, E. J.·Rios, A. C.·Alieva, M.
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Abstract

Obtaining quantitative measurements from live 3D microscopy remains difficult to implement across research settings, particularly without profound image-analysis expertise. We present BEHAV3D-Explorer, an interactive, user-friendly platform that uses natural-language guidance to help users select analysis strategies, tune parameters and configure workflows. BEHAV3D-Explorer enables time-resolved behavioral classification and integrates it with morphological, interaction and functional analyses, thereby connecting dynamic readouts to yield interpretable results across imaging applications.

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de Blank, S., Rios-Jimenez, E., Rubio-Munoz, A., Hoffman, O., Vervoort, B. M. T., Wezenaar, A. K. L., Mazalo, J. K., Molina-Moreno, M., Chang, H.-F., Wehrens, E. J., Rios, A. C., Alieva, M.. 2026-11-09. BEHAV3D-Explorer enables natural language-assisted profiling of 3D cellular dynamics. https://doi.org/10.64898/2026.11.06.764820

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