Rapid Detection and Initial Treatment of Life-Threatening Subdural Hematoma in a Sheep Model

Brody, D. L.; Dengler, B. A.; Angelo, J. P.; Blodgett, D. W.; Cohen, A. B.; Drewry, D. G.; Fitch, M. J.; Goonasekeram, N.; Januszkiewicz, A. J.; Knapp, T.; Kohler, B.; Mark, J.; McAdams, I. S.; Perrino, K. M.; Rodriguez, C. L.; Sleasman, T. A.; Spicer, G. L.; Steiner, N. E.; Vieth, A. P.; Wathen, J. J.; Wolfe, K. C.

doi:10.64898/2026.11.03.763711

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bioRxiv · 10.64898/2026.11.03.763711

Rapid Detection and Initial Treatment of Life-Threatening Subdural Hematoma in a Sheep Model

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Abstract

Traumatic brain injury (TBI) is the leading cause of death and disability in people under 40 worldwide. There is an unmet need for detection and treatment of life-threatening TBI when computed tomography (CT) scanners and neurosurgeons are unavailable. We developed a new handheld frequency-domain multidetector infrared hemorrhage detection device. Using the new device, military pre-hospital medics required <4 minutes to detect life-threatening subdural hematoma in a sheep model. We developed a second device that allows non-neurosurgeons to safely create a burr hole and partially remove clotted subdural blood. In sheep, the treatment device reduced intracranial pressure within 20 minutes, and improved post-anesthesia blinded neurological outcomes. With human use adaptation, these devices could allow rapid detection and initial treatment of some life-threatening TBIs in challenging situations.

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Brody, D. L., Dengler, B. A., Angelo, J. P., Blodgett, D. W., Cohen, A. B., Drewry, D. G., Fitch, M. J., Goonasekeram, N., Januszkiewicz, A. J., Knapp, T., Kohler, B., Mark, J., McAdams, I. S., Perrino, K. M., Rodriguez, C. L., Sleasman, T. A., Spicer, G. L., Steiner, N. E., Vieth, A. P., Wathen, J. J., Wolfe, K. C.. 2026-11-04. Rapid Detection and Initial Treatment of Life-Threatening Subdural Hematoma in a Sheep Model. https://doi.org/10.64898/2026.11.03.763711

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