Discontinuation of GLP-1RA Treatment Reinstates Binge-Like Eating and Drives Body Weight Past Pre-Treatment Levels in Mice

Hildebrandt, B. A.; Ahmari, S. E.

doi:10.64898/2026.11.02.763781

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bioRxiv · 10.64898/2026.11.02.763781

Discontinuation of GLP-1RA Treatment Reinstates Binge-Like Eating and Drives Body Weight Past Pre-Treatment Levels in Mice

Hildebrandt, B. A.·Ahmari, S. E.

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Abstract

We examined the impact of semaglutide treatment and discontinuation in a pre-clinical model for binge eating. Treatment reduced body weight and palatable food intake in mice with binge-like eating. Discontinuation reinstated binge-like eating and caused body weight to significantly exceed pre-treatment baseline, revealing specific binge-related risk when discontinuing GLP-1RAs.

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Hildebrandt, B. A., Ahmari, S. E.. 2026-11-04. Discontinuation of GLP-1RA Treatment Reinstates Binge-Like Eating and Drives Body Weight Past Pre-Treatment Levels in Mice. https://doi.org/10.64898/2026.11.02.763781

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