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bioRxiv · 10.64898/2026.10.26.762009

A single-plane electrical impedance tomography framework for integrated liver and kidney assessment

Wu, A.·Lai, J.-C.·Ho, M. K.·Ge, J. Q. J.·Gong, N.-j.·Zhou, I. Y.·Wong, M.·Edelman, B. J.·Chan, R. W.
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Abstract

Chronic liver and kidney diseases frequently coexist, but their assessment typically requires separate clinical workflows involving serum-based estimated glomerular filtration rate (eGFR) testing and liver elastography-based controlled attenuation parameter (CAP). Electrical impedance tomography (EIT) has recently shown promise for providing portable, non-invasive proxies for both reference measurements. However, existing multi-organ EIT assessment still requires different acquisition protocols for each organ. To simplify this procedure, we assessed the feasibility of a single-plane EIT framework for reconstructing organ-specific images and estimating liver and kidney health from one abdominal belt placement. Across diverse abdominal belt locations, opposite-plane deviation was significantly greater for eGFREIT estimates (2.92%; IQR, 0.46-12.53%) than for CAPEIT estimates (0.94%; IQR, 0.66-1.70%) (p < 0.01). For both organs, compared to images acquired at the conventional organ-specific planes, image correlation significantly decreased (both, p < 0.05) and normalized root mean squared error significantly increased (both, p < 0.05) at the furthest imaging plane, with these differences being numerically larger for the kidney. Together, these results supported the kidney plane as the preferred location for multi-organ assessment. Test-retest evaluation after belt removal and reapplication demonstrated that the correlation between two repeated CAPEIT estimates was just as strong at the kidney plane (R2 = 0.98, p < 0.001) as it was at the conventional liver plane (R2 = 0.97, p < 0.001). Finally, in an independent clinical cohort, kidney-plane CAPEIT estimates were significantly higher in participants with a high metabolic liver-risk profile (i.e. diabetes and high blood pressure) (p < 0.005). CAPEIT estimates also distinguished high and low metabolic risk groups with an AUC of 0.756. Together, these findings support the feasibility of a portable multi-organ EIT imaging framework capable of extracting complementary liver and kidney information from a single belt placement.

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Wu, A., Lai, J.-C., Ho, M. K., Ge, J. Q. J., Gong, N.-j., Zhou, I. Y., Wong, M., Edelman, B. J., Chan, R. W.. 2026-10-30. A single-plane electrical impedance tomography framework for integrated liver and kidney assessment. https://doi.org/10.64898/2026.10.26.762009

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