STING deficiency extends median lifespan and mitigates age-related liver pathology in mice

Martinez, J. C. C.; Kim, S. J.; Cutting, J.; Sedivy, J. M.; Seluanov, A.; Gorbunova, V.

doi:10.64898/2026.10.16.759663

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bioRxiv · 10.64898/2026.10.16.759663

STING deficiency extends median lifespan and mitigates age-related liver pathology in mice

Martinez, J. C. C.·Kim, S. J.·Cutting, J.·Sedivy, J. M.·Seluanov, A.·Gorbunova, V.

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Abstract

The cGAS-STING pathway is a major driver of chronic inflammation. While acute STING inhibition can reduce neuroinflammation and tissue damage, its long-term impact on longevity remains unknown. Here, we demonstrate that genetic deletion of STING extends median lifespan in mice. This survival benefit is accompanied by a marked resistance to age-related hepatic decline. Our findings demonstrate that targeting STING is a promising therapeutic target to extend healthy lifespan.

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Martinez, J. C. C., Kim, S. J., Cutting, J., Sedivy, J. M., Seluanov, A., Gorbunova, V.. 2026-10-19. STING deficiency extends median lifespan and mitigates age-related liver pathology in mice. https://doi.org/10.64898/2026.10.16.759663

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