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bioRxiv · 10.64898/2026.10.12.758599

Cardioselective β-blocker Therapy Resolves Staphylococcus aureus Toxin-Induced Innate Immunoparalysis

Sun, J. W.·Siew, R.·Gonzalez, D. J.·Luna, B.·Kanaji, S.·Sakoulas, G.
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Abstract

During Staphylococcus aureus sepsis, the pore-forming -toxin (Hla) triggers lytic platelet death and provokes the release of catecholamines that modulate leukocyte effector function. The resulting surge in catecholaminergic action paralyzes host antimicrobial capacity by upregulating interleukin-10 (IL-10), profoundly suppressing the protective interferon (IFN) response to orchestrate innate immunoparalysis. Here, we deconvolute a multi-cellular regulatory pathway in the blood and highlight a pivotal immunological checkpoint, where pharmacological intervention with cardioselective {beta}-blockers uncouples the immunosuppressive cascade, restores host antimicrobial function, and significantly improves survival outcomes.

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Sun, J. W., Siew, R., Gonzalez, D. J., Luna, B., Kanaji, S., Sakoulas, G.. 2026-10-13. Cardioselective β-blocker Therapy Resolves Staphylococcus aureus Toxin-Induced Innate Immunoparalysis. https://doi.org/10.64898/2026.10.12.758599

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