BioMINTREL expands biological problem solving through cross-disciplinary representations

Dong, J.; Zhang, Y.; Gao, E.; Yang, C.; Wang, J.; Zha, C.; Wu, Z.; Xu, X.; Zhou, J.; Gao, X.

doi:10.64898/2026.10.10.757703

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bioRxiv · 10.64898/2026.10.10.757703

BioMINTREL expands biological problem solving through cross-disciplinary representations

Dong, J.·Zhang, Y.·Gao, E.·Yang, C.·Wang, J.·Zha, C.·Wu, Z.·Xu, X.·Zhou, J.·Gao, X.

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Abstract

Biological research agents often rely on familiar analytical methods, limiting the questions explored in existing data. We introduce BioMINTREL, an AI agent that finds methods from other disciplines and connects them to biological measurements. It can draw on relationships among datasets and complementary ideas from several methods to develop new questions and analyses. We evaluate it on BioMDC-Bench, which assesses 228 possible applications of computational methods to biological tasks. Compared with GPT-5.4 mini and Qwen3.6-35B, BioMINTREL improves F1 agreement with human experts by up to 45.3 percentage points and increases coverage of applications supported by studies published in subsequent years by up to 58.8 percentage points. Four case studies on real data go beyond previous analyses to reveal dose-specific variant effects, constraints on spatial cell communication and routes through perturbation-response states, and identify the sampling needed to test whether rare high-state cells predict later lineage size. These results highlight BioMINTREL's potential to expand questions in existing data and suggest directions for subsequent research.

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Dong, J., Zhang, Y., Gao, E., Yang, C., Wang, J., Zha, C., Wu, Z., Xu, X., Zhou, J., Gao, X.. 2026-10-16. BioMINTREL expands biological problem solving through cross-disciplinary representations. https://doi.org/10.64898/2026.10.10.757703

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