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bioRxiv · 10.64898/2026.10.05.756839

Transcriptional perturbation effects remain structured beyond the leading global trend

Liu, Q.·Zhang, Q.·Chen, Y.·Du, J.-H.·Zhao, S.·Wang, J.
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Abstract

Prior work has described a global transcriptional response to gene perturbation, with many perturbations moving cells along a common direction. We find that perturbations contribute differently to this leading global trend and that substantial organization remains beyond it, including transferable perturbation-specific effects across datasets and a common hierarchy of responsive genes across perturbations. These patterns make simple strategies surprisingly competitive even in predicting effects beyond the leading global component.

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Liu, Q., Zhang, Q., Chen, Y., Du, J.-H., Zhao, S., Wang, J.. 2026-10-11. Transcriptional perturbation effects remain structured beyond the leading global trend. https://doi.org/10.64898/2026.10.05.756839

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