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bioRxiv · 10.64898/2026.09.29.754885

Awake sharp-wave ripples coincide with rhythmic cortical synchronization

Lim, T. H.·Zhang, X.
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Abstract

Analysis of the Allen Institute Visual Coding Neuropixels dataset revealed a ~5 Hz synchronization of visual cortical activity in awake, immobile mice. During bouts of this rhythm, synchronized cortical bursts coincided with changes in the occurrence of sharp-wave ripples (SWRs) and dentate spikes and in SWR properties. Cortical synchronization, SWRs, and dentate spikes were also coordinated with slower pupil-size fluctuation, revealing that awake SWRs are embedded within nested brainwide rhythms.

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Lim, T. H., Zhang, X.. 2026-09-30. Awake sharp-wave ripples coincide with rhythmic cortical synchronization. https://doi.org/10.64898/2026.09.29.754885

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