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bioRxiv · 10.64898/2026.09.28.754984

Altered Aperiodic EEG Activity in Adolescents with Neurofibromatosis Type 1

Litwinczuk, M. C.·Donoghue, T.·Taylor, J.·Pobric, G.·Lea-Carnall, C.·Garg, S.
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Abstract

BackgroundThe balance between excitatory and inhibitory neuronal signalling (E/I balance), proposed as a key mechanism controlling neuronal activity, is disrupted in many neurodevelopmental conditions. One such condition is Neurofibromatosis Type 1, a monogenic neurodevelopmental disorder characterised by increased inhibitory tone. While previous research suggests that E/I balance may be altered in infancy, it is unknown whether E/I balance remains altered during adolescence in NF1. Here we investigated this question using the aperiodic exponent of the resting electroencephalogram (EEG) power spectrum, a proposed electrophysiological index of E/I balance. MethodThe aperiodic exponent of the EEG power spectrum ( 1/f) was estimated for 16 adolescents with NF1 diagnosis aged 11-16, and 16 age- and sex-matched neurotypical controls. General linear models (GLM) were fit to estimate effects of NF1 diagnosis, age and their interaction on aperiodic exponent. We also estimated the peak dominant frequency and power in oscillatory activity of the EEG signal and fitted the same structure of GLM models. Cognitive assessments across domains of memory, executive function and attention were also analysed with GLM to examine brain-cognition associations. ResultsThe NF1 group had higher aperiodic exponent compared to neurotypical controls, but the aperiodic exponent was not associated with cognitive performance. After accounting for aperiodic activity, the NF1 group also had lower dominant oscillatory frequency than the control group. There was no significant interaction between NF1 diagnosis and age on PAF. There were no group differences in peak alpha power. ConclusionsWe demonstrate for the first time that the alterations to aperiodic activity in NF1 are consistent with the proposed mechanism of increased inhibitory tone. These findings show the potential of this paradigm for future pharmacological and brain stimulation trials investigating treatment-related changes in cortical function.

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Litwinczuk, M. C., Donoghue, T., Taylor, J., Pobric, G., Lea-Carnall, C., Garg, S.. 2026-10-07. Altered Aperiodic EEG Activity in Adolescents with Neurofibromatosis Type 1. https://doi.org/10.64898/2026.09.28.754984

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