Effects of modified proprioceptive feedback on intra-muscle synergies: An exploration using muscle vibration

Abstract

We explored the role of proprioceptive feedback from Ia afferents in intra-muscle synergies stabilizing muscle force with the help of muscle vibration, which is known to increase presynaptic inhibition of those afferents to alpha-motoneurons. Healthy young adults performed an accurate three-finger force production task by pressing with the index, middle and ring fingers of the dominant (right) hand. This was done without vibration and with vibration applied to the extrinsic finger flexors, extensors, both muscles, the palm, or biceps brachii. High-density electromyography was used to identify motor units in both finger flexors and extensors. The raster plots of motor units were converted into firing frequency functions and then subjected to principal component analysis to extract stable motor unit groups (MU-modes). The uncontrolled manifold (UCM) analysis was used to quantify the variance components affecting and not affecting force, and the synergy index in the MU-mode space. Contrary to our expectations, the synergy index did not drop under any vibration condition and showed an increase during vibration applied simultaneously to both flexor and extensor muscles. This was primarily associated with a drop in the component of variance affecting the force magnitude. The results speak against an important role of monosynaptic Ia-afferent projections to alpha-motoneurons in the formation of intra-muscle synergies. They suggest that muscle vibration can play the role of a noisy signal decreasing performance-affecting variance via stochastic resonance effects.