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bioRxiv · 10.64898/2026.09.08.750098

PPARδ Expression and Prognosis in Resected Pancreatic Cancer: A Retrospective Single-Centre Study

Adamson, D. J. A.·Walsh, S. V.·Tait, I. S.·Palmer, C. N.
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Abstract

Background: Pancreatic cancer remains one of the most lethal malignancies, with limited curative options and poor long-term outcomes. Nuclear receptors, including PPAR{delta}, have been implicated in tumour progression. Methods: Retrospectively, we analysed 25 resected pancreatic cancer specimens from patients undergoing Whipple!s procedure (pancreatoduodenectomy) between 2000 and 2009. Immunohistochemistry was performed for PPAR{delta}. Tumour and stromal staining were assessed and correlated with clinicopathological features and survival data. Results: PPAR{delta} expression was observed in the majority of samples. This preliminary analysis suggests that PPAR{delta} expression is associated with adverse clinicopathological features and poorer survival. Conclusions: PPAR{delta} immunohistochemistry may identify a subset of pancreatic cancers with more aggressive biology. Larger studies are warranted to validate these findings.

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Adamson, D. J. A., Walsh, S. V., Tait, I. S., Palmer, C. N.. 2026-09-10. PPARδ Expression and Prognosis in Resected Pancreatic Cancer: A Retrospective Single-Centre Study. https://doi.org/10.64898/2026.09.08.750098

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